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Welcome to Bioinformatics Research Laboratory

Bioinformatics is an interdisciplinary research area that draws expertise knowledge from molecular biology, statistics, computer science and machine learning for building infrastructure for knowledge sharing, analyzing high throughput data and discovering knowledge from multitudes of next generation sequencing data sets. The personnel in this lab have the expertise and experience to contribute in the pursuit of achieving genomic medicine. Recently the life scientists have started shifting focus from hypothesis driven research to knowledge discovery from sequencing data, which is partly due to rapid decline of the cost and improved accuracy in sequencing technology. For the same reason, the genomic or the personalized medicine will "soon" be available at your local doctor's office.

It is very exciting to live in the era of next generation sequencing (NGS), which is expected to accelerate the findings of root causes of many complex diseases that are plaguing humanity. While the NGS technology has the potential of realizing such lofty goals, we are far away from achieve them since the software technology is lagging far behind the hardware advancement of NGS. Several challenging computation problems have to be solved before we realize the full potential of NGS technology. Let me list few of them:

  • Management of very large data set for sharing the archiving purposes
  • Efficient and effective analysis of NGS data (DNA-seq, RNA-seq, CHIP-seq, Methyl-seq)
  • Fusion of data from various sources (e.g. genomic data and clinical data)

We focus on developing efficient algorithm for analysis of NGS data, knowledge discovery and data fusion.

We are looking forward to collaborate with other individual researcher or laboratories. We are open to the possibility of participating with your research proposal covering bioinformatics research component. We will also perform sequence analysis on a contract basis.

Collaborators

The Integrative Bioinformatics group at the National Institute of Environmental Health Science (NIEHS), at the Research Triangle Park, NC

Dr. Kevin Gardner, Head, T Cell Transcription Regulation Group, Laboratory of Receptor Biology and Gene Expression, Cancer Research center, NIH.

Dr. John Clifford, Associate Professor in the Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, School of medicine in Shreveport, Louisiana.

Dr. Jun Chung, Assistant Professor in the Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, School of medicine in Shreveport, Louisiana.

Some online portals that we have developed few years back:

Phylogenetic Profiles
Gene Ontology (GO) Similarity metric

 

Bioinformatics Journal Club.
Bimonthly talks on various topics in Bioinformatics. The nature of the talks varies from cutting edge technology to Tutorials to encourage and stimulate young researchers of this field. These talks are opened to anyone who is interested.


 
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